Institut für Pharmazeutische Technologie -
Prof. Dr. Jörg Kreuter

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Expertise

• Einsatz von Nanopartikeln als Arzneistoff- und Nukleinsäure-Träger und als Genfähren
  
• Transport von Arzneistoffen über die Blut-Hirn-Schranke
  
• Transdermaler Transport von Arzneistoffen
  
• Stabilitätsmessungen von Arzneizubereitungen mittels Mikrokalorimetrie
  
  

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Methoden und Geräte

• Gerätschaften zur Nanopartikelherstellung
  
• Photonen-Korrelationsspektrometer
  
• Kryomikrotom
  
• Tierstall für radioaktive Arbeiten
  
• Mikrokaloriemeter
  
  

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Mitarbeiter:

• PD Dr. Klaus Langer
  
  

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Publikationen

• Steiniger SCJ, Kreuter J, Khalansky AS, Skidan IN, Bobruskin AI, Smirnova ZS, Severin SE, Uhl R, Kock M, Geiger KD, Gelperina SE: Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles. Int J Cancer 2004; 109: 759-767.
  
• Latsch S, Selzer T, Fink L, Kreuter J: Crystallisation of estradiol containing TDDS determined by isothermal microcalorimetry, X-ray diffraction, and optical microscopy. Eur J Pharm Biopharm 2003; 56: 43-52.
  
• Reiss S, von Briesen H, Rübsamen-Waigmann H, Kreuter J, Langer K: Human serum albumin-derived nanoparticles for gene delivery. J Controlled Rel 2003; 92: 199-208.
  
• Kreuter J, Shamenkov D, Petrov V, Ramge P, Cychutek K, Koch-Brandt C, Alyautdin R: Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier. J Drug Target 2002; 10: 317-325.
  
• Friese A, Seiller E, Quack G, Lorenz B, Kreuter J: Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacylate) nanoparticles as a parenteral controlled release system. Eur J Pharm Biopharm 2000; 49: 103-109.
  
• Gulyaev AE, Gelperina SE, Skidan IN, Antropov AS, Kivman GY, Kreuter J: Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharm Res 1999; 16: 1564 - 1569.
  
• Selzer T, Radau M, Kreuter J: Use of isothermal heat conduction microcalorimetry to evaluate stability and excipient compatibility of a solid drug. Int J Pharm 1998; 17: 227-241.
  
• Zobel HP, Kreuter J, Werner D, Noe CR, Kümel G, Zimmer A: Cationic polyhexylcyanoacrylate nanoparticles as carriers for antisense oligo-nucleotides. Antisense Nucl Acid Drug Devel 1997; 7: 483-493.
  
• Löbenberg R, Kreuter J: Macrophage targeting of azidothymidine: A promising strategy for AIDS therapy. AIDS Res Human Retrovir 1996; 12: 1709-1715.
  
• Bender AR, von Briesen H, Kreuter J, Duncan IB, Rübsamen-Waigmann H: Efficiency of nano-particles as a carrier system for antiviral agents in human immunodificiency virus-infected human monocytes / macrophages in vitro. Antimicrob Agents Chemother 1996; 40: 1467-1471.
  
• Kreuter J, Alyautdin RN, Kharkevich DA, Ivanov AA: Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles). Brain Res 1995; 674: 171-174.