Institut für Organische Chemie und Chemische Biologie -
Prof. Dr. Michael Göbel

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Expertise

• Die Gruppe von Prof. Göbel befasst sich mit der Synthese von Rezeptormolekülen, die in ihren Wirt-Gast-Komplexen chemische Reaktionen katalysieren. Schwerpunkte liegen auf den Gebieten der stereoselektiven C-C-Verknüpfungen sowie den sequenzspezifischen Nucleinsäurespaltungen. Weitere Themen sind die molekulare Erkennung von Biopolymeren (RNA) sowie die matrizengesteuerte Oligomerisierung von RNA.
  
  

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Methoden und Geräte

• Synthese funktionaler Moleküle.
  
• Molekulare Erkennung und Katalyse durch Anionenrezeptoren.
  
• Niedermolekulare RNA-Liganden
  
• Synthetische Ribonucleasen.
  
• DNA-spaltende synthetische Phosphodiesterasen.
  
• Matrizengesteuerte Oligomerisierung von RNA.
  
  

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Mitarbeiter:

• Dr. Ute Scheffer
  
  

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Publikationen

• Akalay D, Duerner G, Goebel MW: A first case of asymmetric catalysis induced by metal-free bisoxazolines. Eur J Org Chem 2008;: 2365-2368.
  
• Schueller A, Suhartono M, Fechner U, Tanrikulu Y, Breitung S, Scheffer U, Goebel MW, Schneider G: The concept of template-based de novo design from drug-derived molecular fragments and its application to TAR RNA. J Comput-Aided Mol Des 2008; 22:59-68.
  
• Suhartono M, Weidlich M, Stein T, Karas M, Duerner G, Goebel MW: Synthesis of non-natural aromatic alpha -amino acids by a Heck reaction. Eur J Org Chem 2008;: 1608-1614.
  
• Akalay D, Duerner G, Bats JW, Bolte M, Goebel MW: Synthesis of C2-symmetric bisamidines: A new type of chiral metal-free Lewis Acid Analogue interacting with carbonyl groups. J Org Chem 2007; 72:5618-5624.
  
• Givehchi A, Ludwig V, Boden O, Krebs A, Scheffer U, Goebel M, Schneider G: Classification and prediction of tripeptides inhibiting HIV-1 Tat/TAR-RNA interaction using a self-organizing map. Lett Drug Des Discovery 2007; 4:410-416.
  
• Nandi CK, Parui PP, Brutschy B, Scheffer U, Goebel M: Fluorescence correlation spectroscopy at single molecule level on the Tat-TAR complex and its inhibitors. Biopolymers 2007; 89:17-25.
  
• Ludwig V, Krebs A, Stoll M, Dietrich U, Ferner J, Schwalbe H, Scheffer U, Durner G, Gobel MW: Tripeptides from synthetic amino acids block the Tat-TAR association and slow down HIV spread in cell cultures. Chembiochem 2007; 8:1850-1856.
  
• Morgner N, Barth HD, Schmidt TL, Heckel A, Scheffer U, Göbel M, Fucini P, Brutschy B: Detecting Specific Ligand Binding to Nucleic Acids: A Test for Ultrasoft Laser Mass Spectrometry. Z Phys Chem 2007; 221:689-704.
  
• Tanrikulu Y, Nietert M, Scheffer U, Proschak E, Grabowski K, Schneider P, Weidlich M, Karas M, Goebel M, Schneider G: Scaffold hopping by fuzzy pharmacophores and its application to RNA targets. ChemBioChem 2007; 8:1932-1936.
  
• Gnaccarini C, Peter S, Scheffer U, Vonhoff S, Klussmann S, Göbel MW: Site Specific Cleavage of RNA by a Metal Free Artificial Nuclease Attached to Antisense Oligonucleotides. J Am Chem Soc 2006; 128:8063-8067.
  
• Renner S, Ludwig V, Boden O, Scheffer U, Göbel MW, Schneider G: New inhibitors of the Tat-TAR RNA interaction found with a fuzzy pharmacophore model. ChemBioChem 2005; 6:1119-1125.
  
• Riguet E, Désiré J, Boden O, Ludwig V, Göbel M, Bailly C, Décout J-L: Neamine dimers targeting the HIV-1 TAR RNA. Bioorg Med Chem Lett 2005; 15:4651-4655.
  
• Scheffer U, Strick A, Ludwig V, Peter S, Kalden E, Göbel MW: Metal-Free Catalysts for the Hydrolysis of RNA Derived from Guanidines, 2- Aminopyridines, and 2 Aminobenzimidazoles. J Am Chem Soc 2005; 127:2211-2217.
  
• Scheffer U, Göbel M: Fluorescence-Based On-Line Detection as an Analytical Tool in RNA Electrophoresis. In Oligonucleotide Synthesis: Methods and Applications.P. Herdewijn, ed., 2004;: 261-272.
  
• Hey M, Hartel C, Göbel MW: Nonenzymatic Oligomerization of Ribonucleotides: Towards in vitro Selection Experiments. Helv Chim Acta 2003; 86:844-854.
  
• Krebs A, Ludwig V, Boden O, Göbel MW: Targeting the HIV Trans-Activation Responsive Region–Approaches Towards RNA-Binding Drugs. ChemBioChem 2003; 4:972-978.
  
• Pitsch S, Scheffer U, Hey M, Strick A, Göbel MW: On Facts and Artefacts: The Difficulty to Evaluate an Artificial Nuclease. Helv Chim Acta 2003; 86:3740-3752.
  
• Tsogoeva SB, Dürner G, Bolte M, Göbel MW: C2-Chiral Bis(Amidinium)-Catalyst for a Diels-Alder Reaction Constituting the Key Step of the Quinkert-Dane Estrone Synthesis. Eur J Org Chem 2003;: 1661-1664.